Fatty Liver Disease,

Fatty liver disease means that you have fat inside your liver that can, over time, affect liver function and cause liver injury. People who drink too much alcohol may also have fat in their liver, but that condition is different from fatty liver disease.

Types of fatty liver disease

Health care providers divide fatty liver disease into two types. If you just have fat but no damage to your liver, the disease is called fatty liver disease (NAFLD). If you have fat in your liver plus signs of inflammation and liver cell damage, the disease is called steatohepatitis (NASH).

Symptoms

The majority of individuals with NAFLD have no symptoms and a normal examination. Children may exhibit symptoms such as abdominal pain, which may be in the center or the right upper part of the abdomen, and sometimes fatigue. However, other causes of abdominal pain and fatigue should be considered. On physical examination the liver might be slightly enlarged and some children may have patchy, dark discoloration of the skin present (acanthosis nigricans) most commonly over the neck and the under arm area.

Symptoms from NASH may include:

Severe tiredness
Weakness
Weight loss
Yellowing of the skin or eyes
Spiderlike blood vessels on the skin
Long-lasting itching

NASH that turns into cirrhosis could cause symptoms like fluid retention, internal bleeding, muscle wasting, and confusion. People with cirrhosis over time may develop liver failure and need a liver transplant.

Risk Factors

NAFLD is a very common disorder affecting and may affect as many as one in three to one in five adults and around one in ten children in the United States. Obesity is thought to be the most common cause of fatty infiltration of the liver. Some experts estimate that about two thirds of obese adults and half of obese children may have fatty liver. About 2 to 5 percent of adult Americans and up to 20 percent of those who are obese may suffer from the more severe condition NASH. The number of children who have NASH is not known. The presence of type 2 diabetes and other conditions associated with insulin resistance, such as polycystic ovarian syndrome are know risk factors for the development of fatty liver and NASH.

If you have NAFLD without any other medical problems, you don’t need any special But making some lifestyle changes can control or reverse the fat buildup in your liver. These may include:

Losing weight
Lowering your cholesterol and triglycerides
Controlling your diabetes
Avoiding alcohol

If you have NASH, no medication is available to reverse the fat buildup in your liver. In some cases, the liver damage stops or even reverses itself. But in others, the disease continues to progress. If you have NASH, it’s important to control any conditions that may contribute to fatty liver disease. and lifestyle changes may include:

Losing weight
Medication to reduce cholesterol or triglycerides
Medication to reduce blood pressure
Medication to control diabetes
Avoiding alcohol
Seeing a liver specialist

Some medications are being studied as possible for NASH. These include antioxidants like vitamin E. Scientists are also studying some new diabetes medications for NASH that may be given even if you don't have diabetes. However, you should only take these medicines after consulting with a liver specialist.

Complications

The main complication of fatty liver disease is the progression of NASH to cirrhosis. Cirrhosis means permanent scarring and hardening of the liver.

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